Alicia and I just got back from the West Coast Protein Crystallography Workshop down in in Asilomar, CA. Close to home, but still a treat to visit! We heard a ton of great science--MicroED from Tamir Gonen, amazing science animations from Janet Iwasa, and a ChimeraX tutorial from Tom Goddard, plus Alicia took home a prize for her poster on the CRY1:CLOCK:BMAL1 complex. Thanks to organizers Chris Hill and Heidi Schubert for a lively meeting!
Niki and Jansen's paper on the structural basis of the day-night switch in the cyanobacterial clock is out in Science this week! This terrifically fun collaboration with Andy LiWang's lab at UC Merced and Susan Golden's lab at UC San Diego began after Andy's lab discovered that one of the Kai clock proteins, KaiB, undergoes a rare metamorphosis to an active, fold-switched state. With Andy's mutations in hand to 'lock' KaiB into its active fold, we were able to capture several